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Analysis on damage causes of built-in corridor in core rock-fill dam on thick overburden: A case study

Jia’ao YU; Zhenzhong SHEN; Zhangxin HUANG

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 6,   Pages 762-780 doi: 10.1007/s11709-022-0847-8

Abstract: corridor in core rock-fill dam on thick overburden is extremely complex, which may produce cracking and damageoverburden on the stress and deformation of the built-in corridor in a rock-fill dam, and ascertain the damagecauses of the corridor.Results demonstrate that the damage causes of the corridor are the deformability difference between themodel considering dam construction process, contact between concrete and surrounding soil, and concrete damage

Keywords： thick overburden     built-in corridor     stress     deformation     causes for damage     concrete damaged plasticity    

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Prevalence and causes of air pollution and lung cancer in Xuanwei City and Fuyuan County, Yunnan Province

Yi Cao, Huaping Gao

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 217-220 doi: 10.1007/s11684-012-0192-8

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The Major Root Causes of Smog in China and Technologies and Solutions to Reduce It

Ke Liu

Frontiers of Engineering Management 2016, Volume 3, Issue 4,   Pages 343-348 doi: 10.15302/J-FEM-2016053

Abstract: This paper discusses the two major root causes of smog in China.

Keywords： smog     emissions     coal refining     coal utilization     solutions    

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Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Frontiers of Medicine   Pages 957-971 doi: 10.1007/s11684-023-0988-8

Abstract: Primary ciliary dyskinesia (PCD) is a congenital, motile ciliopathy with pleiotropic symptoms. Although nearly 50 causative genes have been identified, they only account for approximately 70% of definitive PCD cases. Dynein axonemal heavy chain 10 (DNAH10) encodes a subunit of the inner arm dynein heavy chain in motile cilia and sperm flagella. Based on the common axoneme structure of motile cilia and sperm flagella, DNAH10 variants are likely to cause PCD. Using exome sequencing, we identified a novel DNAH10 homozygous variant (c.589C > T, p.R197W) in a patient with PCD from a consanguineous family. The patient manifested sinusitis, bronchiectasis, situs inversus, and asthenoteratozoospermia. Immunostaining analysis showed the absence of DNAH10 and DNALI1 in the respiratory cilia, and transmission electron microscopy revealed strikingly disordered axoneme 9+2 architecture and inner dynein arm defects in the respiratory cilia and sperm flagella. Subsequently, animal models of Dnah10-knockin mice harboring missense variants and Dnah10-knockout mice recapitulated the phenotypes of PCD, including chronic respiratory infection, male infertility, and hydrocephalus. To the best of our knowledge, this study is the first to report DNAH10 deficiency related to PCD in human and mouse models, which suggests that DNAH10 recessive mutation is causative of PCD.

Keywords： DNAH10     mice     motile cilia     mutation     primary ciliary dyskinesia    

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Repetitive transcranial magnetic stimulation causes significant changes of chemical substances in the

GUO Tiecheng, CAO Xuebing, XIA Limin

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 406-409 doi: 10.1007/s11684-008-0078-y

Abstract: More and more studies have reported the usefulness of repetitive transcranial magnetic stimulation (rTMS) in the treatment of stroke patients. This article is to explore if rTMS can cause changes of such chemical substances as N-acetylaspartate (NAA), choline (Cho) and creatine (Cr) in the surrounding area of experimental intracerebral hematoma of rabbits. A total of 36 rabbits were randomly divided into 3 groups: a control group (group A), a sham rTMS group (group B) and an rTMS group (group C). The experimental intracerebral hemorrhage (ICH) was induced by intracerebral injection of self-body blood of the animals in groups B and C, while those of the group A serving as controls were injected with normal saline. The rabbits of groups B and C were treated with sham and real rTMS, respectively, but those of group A were not. The contents of chemical substances including NAA, Cho and Cr in the perihematomal brain tissues were measured by using H-magnetic resonance spectroscopy (H-MRS) 12 hours, 72 hours, 1 week and 2 weeks after the experimental ICH was induced. The results show that the contents of NAA, Cr and NAA/Cr ratio were decreased significantly, but Cho, Cho/Cr increased significantly in groups B and C ( < 0.01) as compared against those in group A. A comparison between the groups B and C revealed that the contents of NAA, Cr, NAA/Cr were higher, but Cho and Cho/Cr were significantly lower in group C than those in group B ( < 0.01). It is concluded that rTMS could result in changes of the chemical substance contents in perihematomal brain tissues, which leads to neuroprotective effects in the brain.
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Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients

Frontiers of Medicine doi: 10.1007/s11684-023-0997-7

Abstract: Primary ciliary dyskinesia (PCD) is a highly heterogeneous recessive inherited disorder. FAP54, the homolog of CFAP54 in Chlamydomonas reinhardtii, was previously demonstrated as the C1d projection of the central microtubule apparatus of flagella. A Cfap54 knockout mouse model was then reported to have PCD-relevant phenotypes. Through whole-exome sequencing, compound heterozygous variants c.2649_2657delinC (p. E883Dfs*47) and c.7312_7313insCGCAGGCTGAATTCTTGG (p. T2438delinsTQAEFLA) in a new suspected PCD-relevant gene, CFAP54, were identified in an individual with PCD. Two missense variants, c.4112A>C (p. E1371A) and c.6559C>T (p. P2187S), in CFAP54 were detected in another unrelated patient. In this study, a minigene assay was conducted on the frameshift mutation showing a reduction in mRNA expression. In addition, a CFAP54 in-frame variant knock-in mouse model was established, which recapitulated the typical symptoms of PCD, including hydrocephalus, infertility, and mucus accumulation in nasal sinuses. Correspondingly, two missense variants were deleterious, with a dramatic reduction in mRNA abundance from bronchial tissue and sperm. The identification of PCD-causing variants of CFAP54 in two unrelated patients with PCD for the first time provides strong supportive evidence that CFAP54 is a new PCD-causing gene. This study further helps expand the disease-associated gene spectrum and improve genetic testing for PCD diagnosis in the future.

Keywords： primary ciliary dyskinesia     CFAP54     cilia    

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China Keeps Carrying Forward the Key Special Project of “Air Pollution Causes and Control”

Huan Liu,Kebin He

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 5, doi: 10.1007/s11783-016-0881-7

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Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 481-489 doi: 10.1007/s11684-016-0494-3

Abstract:

The tumor suppressor gene liver kinase B1 (LKB1), also called STK11, encodes a serine/threonine kinase. LKB1 plays crucial roles in cell differentiation, proliferation, and polarity. In this study, LKB1 conditional knockout mice (LKB1Pax2 CKO mice) were generated using Pax2-Cre mice to investigate the function of LKB1 in inner ear hair cells during early embryonic period. LKB1Pax2 CKO mice died perinatally. Immunofluorescence and scanning electron microscopy revealed that stereociliary bundles in LKB1Pax2 CKO mice were clustered and misoriented, respectively. Moreover, ectopic distribution of kinocilium bundles resulting from abnormal migration of kinocilium was observed in the mutant mice. The orientation of stereociliary bundles and the migration of kinocilia are critical indicators of planar cell polarity (PCP) of hair cells. LKB1 deficiency in LKB1Pax2 CKO mice thus disrupted hair cell planar polarity during embryonic development. Our results suggest that LKB1 is required in PCP formation in cochlear hair cells in mice.

Keywords： LKB1     stereociliary bundles     kinocilium     planar cell polarity     hearing     mice    

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Windborne debris damage prediction analysis

Fangfang SONG, Jinping OU,

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 3,   Pages 326-330 doi: 10.1007/s11709-010-0067-5

Abstract: Windborne debris is one of the most important causes of the envelop destruction according to the post-damageThe problem of windborne debris damage could be summarized as three parts, including windborne debrisBesides, the process of windborne debris damage analysis is described in detail.

Keywords： typhoon     windborne debris     structural envelopes     damage estimation    

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Corrosion damage assessment and monitoring of large steel space structures

Bo CHEN, You-Lin XU, Weilian QU,

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 3,   Pages 354-369 doi: 10.1007/s11709-010-0088-0

Abstract: This paper proposes a framework for assessing the corrosion damage of large steel space structures subjectedreal large steel space structure built in the southern coastal area in China to assess its corrosion damage

Keywords： large steel space structure     atmospheric corrosion     stress corrosion cracking     corrosion damage     damage assessment    

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Detection of damage locations and damage steps in pile foundations using acoustic emissions with deep

Alipujiang JIERULA, Tae-Min OH, Shuhong WANG, Joon-Hyun LEE, Hyunwoo KIM, Jong-Won LEE

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 2,   Pages 318-332 doi: 10.1007/s11709-021-0715-y

Abstract: The aim of this study is to propose a new detection method for determining the damage locations in pileFirst, the damage location is simulated using a back propagation neural network deep learning model withIn particular, the damage location is identified using two parameters: the pile location ( ) and theSecond, the damage step condition is determined using a classification model with an acoustic emissionFinally, a new damage detection and evaluation method for pile foundations is proposed.

Keywords： pile foundations     damage location     acoustic emission     deep learning     damage step    

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Creep life assessment of aero-engine recuperator based on continuum damage mechanics approach

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 4, doi: 10.1007/s11465-022-0702-6

Abstract: The creep life of an aeroengine recuperator is investigated in terms of continuum damage mechanics by

Keywords： creep     life assessment     brazed joint     continuum damage mechanics     aeroengine recuperator    

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Bacterial inactivation, DNA damage, and faster ATP degradation induced by ultraviolet disinfection

Chao Yang, Wenjun Sun, Xiuwei Ao

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 1, doi: 10.1007/s11783-019-1192-6

Abstract: • Long amplicon is more effective to test DNA damage induced by UV. • ATP in bacteria does not degradeWe used quantitative polymerase chain reaction (qPCR) to investigate DNA damage and evaluated adenosineThe results of qPCR effectively showed the DNA damage induced by UV when using longer gene amplicons,

Keywords： UV disinfection     DNA damage     qPCR     ATP    

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The damage evolution behavior of polypropylene fiber reinforced concrete subjected to sulfate attack

Ninghui LIANG; Jinwang MAO; Ru YAN; Xinrong LIU; Xiaohan ZHOU

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 3,   Pages 316-328 doi: 10.1007/s11709-022-0810-8

Abstract: To study the damage evolution behavior of polypropylene fiber reinforced concrete (PFRC) subjected toeffect of sulfate attack relative to time and fiber hybridization were analyzed and the compression damageThe initial damage factor of hybrid PFRC was −0.042 and −0.056 respectively after 150 d of corrosion,

Keywords： polypropylene fiber reinforced concrete     sulfate attack     damage evolution behavior     acoustic emission     damage factor    

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Spectral element modeling based structure piezoelectric impedance computation and damage identification

Zhigang GUO, Zhi SUN

Frontiers of Structural and Civil Engineering 2011, Volume 5, Issue 4,   Pages 458-464 doi: 10.1007/s11709-011-0133-7

Abstract: paper presents a numerical simulation study on electromechanical impedance technique for structural damageThe basic principle of impedance based damage detection is structural impedance will vary with the occurrenceand development of structural damage, which can be measured from electromechanical admittance curvesTherefore, structure damage can be identified from the electromechanical admittance measurements.In this study, a model based method that can identify both location and severity of structural damage

Keywords： PZT     piezoelectric impedance     optimization     spectral element     damage identification    

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Title Author Date Type Operation

Analysis on damage causes of built-in corridor in core rock-fill dam on thick overburden: A case study

Jia’ao YU; Zhenzhong SHEN; Zhangxin HUANG

Journal Article

Prevalence and causes of air pollution and lung cancer in Xuanwei City and Fuyuan County, Yunnan Province

Yi Cao, Huaping Gao

Journal Article

The Major Root Causes of Smog in China and Technologies and Solutions to Reduce It

Ke Liu

Journal Article

Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Journal Article

Repetitive transcranial magnetic stimulation causes significant changes of chemical substances in the

GUO Tiecheng, CAO Xuebing, XIA Limin

Journal Article

Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients

Journal Article

China Keeps Carrying Forward the Key Special Project of “Air Pollution Causes and Control”

Huan Liu,Kebin He

Journal Article

Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Journal Article

Windborne debris damage prediction analysis

Fangfang SONG, Jinping OU,

Journal Article

Corrosion damage assessment and monitoring of large steel space structures

Bo CHEN, You-Lin XU, Weilian QU,

Journal Article

Detection of damage locations and damage steps in pile foundations using acoustic emissions with deep

Alipujiang JIERULA, Tae-Min OH, Shuhong WANG, Joon-Hyun LEE, Hyunwoo KIM, Jong-Won LEE

Journal Article

Creep life assessment of aero-engine recuperator based on continuum damage mechanics approach

Journal Article

Bacterial inactivation, DNA damage, and faster ATP degradation induced by ultraviolet disinfection

Chao Yang, Wenjun Sun, Xiuwei Ao

Journal Article

The damage evolution behavior of polypropylene fiber reinforced concrete subjected to sulfate attack

Ninghui LIANG; Jinwang MAO; Ru YAN; Xinrong LIU; Xiaohan ZHOU

Journal Article

Spectral element modeling based structure piezoelectric impedance computation and damage identification

Zhigang GUO, Zhi SUN

Journal Article